red root and detoxification pathways (ie cytochrome p450 etc)

topic posted Wed, October 14, 2009 - 10:51 PM by 
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I was just doing some research on red root, and I'm not coming up with much on how it's metabolized and what it does to liver detoxification pathways like cytochrome p450 (which is of interest to me in looking up 'drug interactions' and learning how it affects dosage of drugs and other herbs). It seems that since it affects the liver, there must be some material on that 'out there'. I'm not reading any journal databases, just did an internet sear5ch, but i'm surprised at how little there is on this important herb.
Anyone know?
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  • Michael Moore has a nice write up in "Medicinal Plants of the Pacific West" where he sings the praises of Red Root for treating platelet aggregation. There is a list of constituents there as well as contraindications where he gives minor warnings for people on drugs related to blood clotting and people allergic to aspirin. Further, he does suggest not using Red Root if on medical care for an overt disease saying that Redroot is for healthy people who are stressed no sick folks under treatment.

    This is from his website:

    PLATELET AGGREGATION Platelets are the small, rather uniform fragments of
    large bone marrow cells that aid the blood in coagulation, hemostasis,
    inflammation, and thrombus formation. Mild subclotting and sticking is a
    common early condition that can lead to thrombosis, atherosclerosis, and
    strokes, and can be helped by an aspirin a day, better fat digestion, and
    Ceanothus.

    Also from Jim Dukes wonderful Plant Phytochemical Database Ceanothus is know to contain the following (more info in the database):

    - BETULIN Root Bark: JAD

    - BETULINIC-ACID Root Bark 200 ppm; PHYT13:2002 200 - 7,279 ppm JAD

    Database:
    www.ars-grin.gov/duke/

    And yes, I would agree that very little is know of this amazing plant.

    Good luck,

    D

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